03/03/2013 0 Comments

U.S. researchers have determined that the AdenoPlus test is both sensitive and specific at detecting adenoviral conjunctivitis. Of the 128 patients presenting with a clinical diagnosis of acute viral conjunctivitis who were enrolled in this prospective, sequential, masked and multicenter trial, the tear fluid of 36 patients was found to be positive for adenovirus either by viral cell culture with confirmatory immunofluorescence assay or polymerase chain reaction, while 29 patients results were found to be positive by both CC-IFA and PCR. When compared only with CC-IFA, AdenoPlus showed a sensitivity of 90 percent (28/31) and specificity of 96 percent (93/97). When compared only with PCR, AdenoPlus showed a sensitivity of 85 percent (29/34) and a specificity of 98 percent (89/91). When compared with both CC-IFA and PCR, AdenoPlus showed a sensitivity of 93 percent (27/29) and a specificity of 98 percent (88/90). When compared with PCR, CC-IFA showed a sensitivity of 85 percent (29/34) and specificity of 99 percent (90/91).
JAMA Ophthalmol 2013;131:17-22
Sambursky R, Trattler W, Tauber S, Starr C, et a

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