08/23/2010 0 Comments

Patients with ocular hypertensive eyes showing abnormal Moorfields Regression Analysis and Glaucoma Probability Score classifications at presentation may be at increased risk of Heidelberg Retina Tomograph or visual field change, says a new study from UCL Institute of Ophthalmology in London.

In an evaluation to determine the ability of HRT, MRA and GPS classifications at baseline to predict glaucomatous progression in ocular hypertensive eyes, 198 effected patients underwent regular HRT and VF testing from 1993 to 2001. HRT progression was assessed using linear regression of rim area/time. VF progression was assessed by pointwise linear regression of sensitivity/time. Subjects were classified as progressing or stable at the end of the study period. The relationship between baseline abnormal (outside normal limits combined with borderline classification) MRA and GPS classification and progression status was assessed by odds ratios.

Results showed that an abnormal, superotemporal MRA was the only classification found to be predictive of HRT progression in isolation (OR: 3.05, 1.25 to 7.47). Abnormal global, superotemporal, superonasal and temporal MRA classifications were all associated with significant ORs for predicting HRT or VF progression (OR range: 1.77 to 2.54). Abnormal GPS classifications were not predictive of disease behavior. Combined abnormal GPS and MRA classifications were associated with higher ORs than either classification in isolation.

J Glaucoma 2010;19:304-9
Strouthidis NG, Gardiner SK, Owen VM, et al.

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